Without resolving mixtures of Formoterol fumarate dihydrate and Beclomethasone dipropionate, simultaneous estimation has been successfully achieved by spectrophotometry. Simultaneous equation method employs formation and solving of mathematical simultaneous equation using 214nm and 239nm wavelength of Formoterol fumarate dihydrate and Beclomethasone dipropionate respectively in methanol. Linearity was obtained in concentration range of 0.1-0.6 �µg/ml and 5-30 �µg/ml respectively for Formoterol fumarate dihydrate and Beclomethasone dipropionate. The method is successfully applied to pharmaceutical formulation, with no interference from excipients. The proposed method is simple, accurate for routine simultaneous estimation of Formoterol fumarate dihydrate and Beclomethasone dipropionate.
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